Gout

Gout is an arthritic condition that produces excruciating pain, swelling, and inflammation in a single joint (although more than one may be affected). It usually affects your big toe, but it can also affect other joints in your foot, ankles, knees, wrists, and hands. The discomfort normally begins in the middle of the night while you’re sleeping and gradually worsens over a few hours. The symptoms occur due to a build-up of uric acid in the blood and this causes uric acid crystals to deposit in the joints.